There are only two ways to conquer destiny or be independent of it. One is to enquire for whom is this destiny, and discover that only the ego is bound by destiny and not the Self, and that the ego is non-existent.
The other way is to kill the ego by completely surrendering to the Lord, by realising one's helplessness and saying all the time, 'Not I, but Thou Oh Lord' and giving up all sense of 'I' and 'mine, and leaving it to the Lord to do what he likes with you.
Complete effacement of the ego is necessary to conquer destiny, whether you achieve this effacement through Self-enquiry or Bhakti Marga (Path of Devotion).
-- Gems from Bhagavan